Individuals Stopping Slimming Injections Put On Weight Far More Rapidly Than Those on Conventional Diets

New research reveals that individuals who come off popular weight-loss injections like semaglutide or tirzepatide tend to recover lost weight much more quickly than those who stop traditional diet and exercise programs.

Published data in a major medical journal shows that while obese people often shed about a fifth of their body weight while undergoing treatment, the weight returns at an average rate of nearly a kilo each month once they quit.

"People buying these drugs must be aware of the danger of quick rebound weight gain when the treatment is stopped," warns lead investigator Dr. Susan Jebb.

This pace of regain suggests a return to original weight in about 18 months.

Analyzing Approaches

The research, which examined dozens of studies involving over 9,000 of participants, contrasted the effects of these new drugs with other pills.

The team point out that people who shed pounds through lifestyle changes alone generally have a more gradual creep back—approximately 0.1 kg a month—after stopping.

Explaining the Fast Rebound

Doctors believe the mechanism of the drugs accounts for the amplified weight return.

These medications copy a natural hormone called GLP-1, which controls hunger.

"Long-term administration of GLP-1 levels far above than normal might result in the system to produce less of its own natural hormone, and may also reduce responsiveness to its effects," explained Dr. Adam Collins, a dietetics specialist.

"Withdrawal of this medication means hunger is unsuppressed, making excessive eating much more probable."

A Chronic Issue?

Health authorities recommend the injections for people with obesity-related medical conditions, accompanied by prescribed lifestyle changes.

A number of clinicians say that, due to the likelihood of weight regain, the treatment should be considered long-term.

This view is reinforced by drug manufacturers, who note that the findings "emphasize the persistent nature of excess weight," similar to managing diseases like high blood pressure.

User Experiences

People who have come off the jabs explain a powerful resurgence of cravings.

"I experienced a switch flipping and you become starving," said one woman.

The struggle is worsened if patients have not adopted sustainable dietary or behavioural modifications during treatment.

Significant Adoption

Survey data indicate that a significant number of adults in the UK have used weight-loss jabs in the past year, with desire remaining high.

• Use is higher among women compared to males.
• The 40s and 50s demographic shows the greatest level of interest.
• Many access the drugs through private healthcare rather than the NHS.

Ultimately, clinicians caution that while the jabs are potent tools for shedding pounds, they are not a permanent solution and lasting health benefits likely depends on combined behavioural support.